Dr. Clair Francomano attended Yale College as an undergraduate and received her M.D. from Johns Hopkins University School of Medicine. She trained in Internal Medicine and Medical Genetics at Johns Hopkins and joined the full-time Hopkins faculty in 1984. In 1994 she became Chief of the Medical Genetics Branch at the National Human Genome Research Institute, National Institutes of Health, where she served as Clinical Director from 1996–2001. From 2001–2005 she was Chief of the Human Genetics and Integrative Medicine Section in the Laboratory of Genetics, National Institute on Aging. Her research interests over the years have centered on Hereditary Disorders of Connective Tissue and Skeletal Dysplasias. She joined the Greater Baltimore Medical Center in 2005 as Director of Adult Genetics at the Harvey Institute of Human Genetics.
Dr. Francomano has been involved in the care of patients with Ehlers-Danlos syndrome throughout her career. During her years at the National Institutes of Health she spearheaded a longitudinal study on the natural history of EDS that ran for over 20 years. She is currently the Director of The Ehlers-Danlos Society Center for Clinical Care and Research at the Harvey Institute of Human Genetics, Greater Baltimore Medical Center.